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CD141 (PN0236) Nb-FC recombinant antibody

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Article Number: PA0187
Delivery time: 现货
Price: 100ug/2200
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Target: CD8
Application: ELISA, FC
Reactivity : Human

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Detailed Information

Recommended dilution ratio : ELISA 1:5000-100000; Flow Cyt 1-2μg/Test
Compose : Phosphate-buffered solution
Source : Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
Purification process : Recombinant Expression and Affinity purified
Storage : -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
Concentration : Please check the information on the tube
Clonality : Monoclonal
Clone Number : PN0569

Antigen & Target Information

Specificity : This recombinant monoclonal antibody can detects endogenous levels of CD8 protein.
Gene name : CD8A MAL
Protein Name : Thrombomodulin (TM) (Fetomodulin) (CD antigen CD141)
Alias : Thrombomodulin; TM; Fetomodulin; CD antigen CD141;

Database connection:

Organism

Gene ID

SwissProt

Background:

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found forThis gene. [provided by RefSeq, Nov 2011]

Cell localization : [Isoform 1]: Cell membrane; Single-pass type I membrane protein. CD8A localizes to lipid rafts only when associated with its partner CD8B. .; [Isoform 2]: Secreted .

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