Signaling pathway

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FOXP3 Polyclonal Antibody

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Article Number: PD2564
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: FOXP3
Application: WB, IHC, IF, ELISA
Reactivity : Human,Mouse,Rat,Pig
MW(Observed) : 47 kD
Host Species: Rabbit
Isotype : IgG

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Detailed Information

Recommended dilution ratio : WB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:20000; IF 1:50-200
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : FOXP3 Polyclonal Antibody detects endogenous levels of FOXP3 protein.
Gene name : FOXP3
Protein Name : Forkhead box protein P3
Alias : FOXP3;IPEX;JM2;Forkhead box protein P3;Scurfin

Database connection:

Organism

Gene ID

SwissProt

Background:

The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],

Cell localization : Nucleus . Cytoplasm . Predominantly expressed in the cytoplasm in activated conventional T-cells whereas predominantly expressed in the nucleus in regulatory T-cells (Treg). The 41 kDa form derived by proteolytic processing is found exclusively in the chromatin fraction of activated Treg cells (By similarity). .

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