Signaling pathway

Contact Us

15392937510

Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510

Image Name

CD131 (PN0002) Nb-FC recombinant antibody

Copy

Download
Article Number: PA0632
Delivery time: 现货
Price: 100ug/2200
+


Target: CD45
Application: ELISA
Reactivity : Human

隐藏域元素占位

Detailed Information

Recommended dilution ratio : ELISA 1:5000-100000; Flow Cyt 1-2μg/Test
Compose : Phosphate-buffered solution
Source : Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
Purification process : Recombinant Expression and Affinity purified
Storage : -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
Concentration : Please check the information on the tube
Clonality : Monoclonal
Clone Number : PN0539

Antigen & Target Information

Specificity : This recombinant monoclonal antibody can detects endogenous levels of CD45 protein.
Gene name : PTPRC CD45
Protein Name : Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131)
Alias : IL-3R common β chain; CDw131; Beta-C antibody; CD131 antibody; CDw131 antibody; Colony stimulating factor 2 receptor beta antibody; Colony stimulating factor 2 receptor beta low affinity; granulocyte macrophage; antibody; Common beta chain antibody; Csf2rb antibody; Cytokine receptor common beta chain antibody; Cytokine receptor common beta chain precursor; CDw131 antigen; antibody; Cytokine receptor common subunit beta antibody; GM CSF/IL 3/IL 5 receptor common beta chain antibody; GM-CSF/IL-3/IL-5 receptor common beta subunit antibody; granulocyte-macrophage colony-stimulating factor receptor; beta antibody; IL3RB antibody; IL3RB_HUMAN antibody; IL5RB antibody; Interleukin 3 receptor; beta antibody; Interleukin 3 receptor/granulocyte macrophage colony stimulating factor 3 receptor beta; high affinity; antibody; Interleukin 5 receptor; beta antibody; SMDP5 antibody; stimulating factor 3 receptor; beta; high affinity; antibody;

Database connection:

Organism

Gene ID

SwissProt

Background:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which enc

Cell localization : Cell membrane; Single-pass type I membrane protein. Membrane raft. Colocalized with DPP4 in membrane rafts.

Recommended

Relevant Literature

Leave a message for inquiry

Please leave your inquiry, and we will contact you as soon as possible.

Submit