Signaling pathway

Contact Us

15392937510

Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510

Image Name

Vav (phospho Tyr160) Polyclonal Antibody

Copy

Download
Article Number: PF0949
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
+


Target: VAV1
Application: IHC, IF, ELISA
Reactivity : Human,Mouse,Rat
MW(CalcμLated) : 98kD
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Modify-Modification : Phospho
Recommended dilution ratio : IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : Phospho-Vav (Y160) Polyclonal Antibody detects endogenous levels of Vav protein only when phosphorylated at Y160.
Gene name : VAV1
Protein Name : Proto-oncogene vav
Alias : VAV1;VAV;Proto-oncogene vav

Database connection:

Organism

Gene ID

SwissProt

Background:

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012],

Cell localization : intracellular, cytosol, plasma membrane, cell-cell junction,

Recommended

Relevant Literature

Leave a message for inquiry

Please leave your inquiry, and we will contact you as soon as possible.

Submit