Signaling pathway

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p21 (Acetyl Lys154) rabbit pAb

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Article Number: PS0134
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: p21
Application: WB, ELISA
Reactivity : Human,Mouse,Rat
MW(Observed) : 21 kD
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Modify-Modification : Acetyl
Recommended dilution ratio : WB 1:1000-2000; ELISA 1:5000-20000
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : This antibody detects endogenous levels of Human,Mouse,Rat p21 (Acetyl Lys154)
Gene name : CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1
Protein Name : p21 (Acetyl Lys154)
Alias : CDKN1A;CAP20;CDKN1;CIP1;MDA6;PIC1;SDI1;WAF1;Cyclin-dependent kinase inhibitor 1;CDK-interacting protein 1;Melanoma differentiation-associated protein 6;MDA-6;p21;

Database connection:

Organism

Gene ID

SwissProt

Background:

function:May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.,induction:By p53, mezerein (antileukemic compound) and interferon beta.,PTM:Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA.,similarity:Belongs to the CDI family.,tissue specificity:Expressed in all adult human tissues, with 5-fold lower levels observed in the brain.,

Cell localization : Cytoplasm . Nucleus .

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