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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
Article Number: PG3337
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
Category:
Target： TLR4
Application： IHC,IF
Reactivity ： Human,Mouse,Rat
Host Species： Rabbit
Isotype ： IgG
隐藏域元素占位
Detailed Information
Recommended dilution ratio ： IHC 1:200-500; IF 1:50-200
Compose ： PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Purification process ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage ： -15°C to -25°C/1 year(Do not lower than -25°C
Clonality ： Polyclonal
Antigen & Target Information
Specificity ： The antibody detects endogenous TLR4 protein.
Gene name ： TLR4
Protein Name ： Toll-like receptor 4
Alias ： TLR4;Toll-like receptor 4;hToll;CD284
Background：
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
Cell localization ： Cell membrane; Single-pass type I membrane protein. Early endosome. Cell projection, ruffle. Upon complex formation with CD36 and TLR6, internalized through dynamin-dependent endocytosis (PubMed:20037584). Colocalizes with RFTN1 at the cell membrane and then, together with RFTN1, translocates to endosomes upon lipopolysaccharide stimulation.
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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
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