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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
Article Number: PR0105
Delivery time: 现货
Price: 100 μL/1800
Category:
Target： CD40
Application： FC,IF
Reactivity ： Human
Host Species： Mouse
Isotype ： Mouse IgG1/Kappa
隐藏域元素占位
Detailed Information
Recommended dilution ratio ： IF 1:200-1:1000;FC:1 µg per million cells in 100 µl volume. For optimal results, the reagent should be titrated according to each specific application
Compose ： PBS, pH 7.4
Purification process ： Protein A
Storage ： Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Concentration ： 0.5 mg/mL
Clone Number ： Monoclonal
Antigen & Target Information
Specificity ： Endogenous
Gene name ： CD40
Protein Name ： Tumor necrosis factor receptor superfamily member 5
Alias ： CD40;TNFRSF5;Tumor necrosis factor receptor superfamily member 5;B-cell surface antigen CD40;Bp50;CD40L receptor;CDw40;CD antigen CD40
Background：
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIG
Cell localization ： [Isoform I]: Cell membrane; Single-pass type I membrane protein.; [Isoform II]: Secreted.
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Email: pinuofei2017@163.com
TEL: 15392937510
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