Signaling pathway

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CD68 (PN0473) Nb-FC recombinant antibody

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Article Number: PA0509
Delivery time: 现货
Price: 100ug/2200
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Target: CD142
Application: ELISA
Reactivity : Human

隐藏域元素占位

Detailed Information

Recommended dilution ratio : ELISA 1:5000-100000
Compose : Phosphate-buffered solution
Source : Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
Purification process : Recombinant Expression and Affinity purified
Storage : -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
Concentration : Please check the information on the tube
Clonality : Monoclonal
Clone Number : PN0280

Antigen & Target Information

Specificity : This recombinant monoclonal antibody can detects endogenous levels of CD142 protein.
Gene name : F3
Protein Name : Macrosialin (Gp110) (CD antigen CD68)
Alias : CD68;Macrosialin;Gp110;CD68;CD68 nanobody;

Database connection:

Organism

Gene ID

SwissProt

Background:

CD142, also known as Tissue Factor (TF), Coagulation Factor III, and Thromboplastin, is a 45 kD type I transmembrane glycoprotein. It is expressed on the surface of a variety of cells that are physically separated from the circulating blood which include smooth muscle cells, fibroblasts, keratinocytes, glomerular epithelial cells (cytoplasmic inclusions), astrocytes, myocardium, liver stromal cells, pancreas cells, and is also expressed on activated monocytes and stimulated endothelial cells. CD142 is a high-affinity receptor for coagulation factor VII and initiates the extrinsic pathway of blood coagulation. CD142 also plays an important role in a variety of diseases such as sepsis, atherosclerosis, and cancer.

Cell localization : [Isoform 1]: Membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.

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