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Signaling pathway
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Neurodegeneration—A Common Pathway Across Multiple Diseases (0)
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The AGE–RAGE signaling pathway in diabetic complications (0)
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PD-L1 Expression and the PD-1 Checkpoint Pathway in Cancer (0)
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Glioma-associated Kaposi’s sarcoma-associated herpesvirus infection (0)
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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
Article Number: PL0791
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
Category:
Target： Rb
Application： WB, IF, IP, ELISA
Reactivity ： Human,Mouse,Rat
MW(CalcμLated) ： 106 kDa
MW(Observed) ： 106 kDa
Host Species： Rabbit
Isotype ： IgG, Kappa
Conjugate ： Phospho
隐藏域元素占位
Detailed Information
Modify-Modification ： Ser780
Recommended dilution ratio ： WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200;
Compose ： PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process ： Protein A
Storage ： -15°C to -25°C/1 year(Do not lower than -25°C
Clonality ： Monoclonal
Clone Number ： PT0992R
Antigen & Target Information
Specificity ： Rb (Phospho Ser780) Antibody detects endogenous levels of Rb protein only when phosphorylated at S780.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):TLsPI
Gene name ： RB1
Protein Name ： Retinoblastoma-associated protein
Alias ： RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110
Database connection:
Background：
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008],
Cell localization ： Nucleus . During keratinocyte differentiation, acetylation by KAT2B/PCAF is required for nuclear localization. .
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Centered on our primary and secondary antibody products, we have established a strong foothold in the specialized antibody reagent market. Leveraging our independently developed core technology platform and a dedicated R&D and manufacturing team, we provide high‑reliability biological reagents and end‑to‑end technical solutions to universities, research institutes, biopharmaceutical companies, and other customers worldwide.
Support Services. Since its inception, Pinofibio has remained committed to a development philosophy centered on research needs. Through a robust R&D system, stringent quality control, and responsive, efficient service, the company is dedicated to building an antibody product portfolio that spans multiple species and targets, helping researchers overcome technical challenges and driving innovation in the biopharmaceutical industry.
Wuhan Pinofibio Biotechnology Co., Ltd.
Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
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