Signaling pathway

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Caspase-3 mouse Monoclonal Antibody(5H10)

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Article Number: PH0689
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560

Detailed Information

Recommended dilution ratio : WB: 500-2000; IHC 1:100-200
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Storage : -20°C/1 year
Concentration : 1 mg/ml
Clonality : Monoclonal
Clone Number : 5H10

Antigen & Target Information

Specificity : Caspase-3 protein detects endogenous levels of CASP3
Gene name : CASP3
Protein Name : Caspase3
Alias : CASP3

Database connection:

Organism

Gene ID

SwissProt

Mouse
Background:

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008],

Cell localization : Cytoplasm.

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