Signaling pathway

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TNR18 Polyclonal Antibody

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Article Number: PG5896
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: TNR18
Application: WB, ELISA
Reactivity : Human,Mouse
MW(Observed) : 26 kD
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-2000; ELISA 1:5000-20000
Compose : PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : TNR18 Polyclonal Antibody detects endogenous levels of protein.
Gene name : TNFRSF18 AITR GITR UNQ319/PRO364
Protein Name : Tumor necrosis factor receptor superfamily member 18 (Activation-inducible TNFR family receptor) (Glucocorticoid-induced TNFR-related protein) (CD antigen CD357)

Database connection:

Organism

Gene ID

SwissProt

Mouse
Background:

This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011],

Cell localization : [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.

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