Signaling pathway

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CD223 (PN0521) Nb-FC recombinant antibody

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Article Number: PA0536
Delivery time: 两个月
Price: 100ug/2200
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Target: CD27
Application: ELISA
Reactivity : Human

隐藏域元素占位

Detailed Information

Recommended dilution ratio : ELISA 1:5000-100000
Compose : Phosphate-buffered solution
Source : Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
Purification process : Recombinant Expression and Affinity purified
Storage : -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
Concentration : Please check the information on the tube
Clonality : Monoclonal
Clone Number : PN0506

Antigen & Target Information

Specificity : This recombinant monoclonal antibody can detects endogenous levels of CD27 protein.
Gene name : CD27 TNFRSF7
Protein Name : Lymphocyte activation gene 3 protein (LAG-3) (CD antigen CD223) [Cleaved into: Secreted lymphocyte activation gene 3 protein (sLAG-3)]
Alias : LAG3;FDC;Lymphocyte activation gene 3 protein;LAG-3;Protein FDC;CD223;CD223 nanobody;LAG-3 nanobody

Database connection:

Organism

Gene ID

SwissProt

Background:

CD27 molecule (CD27) Homo sapiens The protein encoded by This gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]

Cell localization : Membrane; Single-pass type I membrane protein.

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