Signaling pathway

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CD8 (PN0371) Nb-FC recombinant antibody

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Article Number: PA0345
Delivery time: 现货
Price: 100ug/2200
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Target: CD166
Application: ELISA, FC
Reactivity : Human

隐藏域元素占位

Detailed Information

Recommended dilution ratio : ELISA 1:5000-100000
Compose : Phosphate-buffered solution
Source : Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
Purification process : Recombinant Expression and Affinity purified
Storage : -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
Concentration : Please check the information on the tube
Clonality : Monoclonal
Clone Number : PN0353

Antigen & Target Information

Specificity : This recombinant monoclonal antibody can detects endogenous levels of CD166 protein.
Gene name : ALCAM MEMD
Protein Name : T-cell surface glycoprotein CD8 alpha chain (T-lymphocyte differentiation antigen T8/Leu-2) (CD antigen CD8a)
Alias : T-cell surface glycoprotein CD8 alpha chain; T-lymphocyte differentiation antigen T8/Leu-2; CD antigen CD8a; CD8 nanobody;

Database connection:

Organism

Gene ID

SwissProt

Background:

This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain.This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011]

Cell localization : Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite. Detected at the immunological synapse, i.e., at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806). Colocalizes with CD6 and the TCR/CD3 complex at the immunological synapse (PubMed:15294938). .; [Isoform 3]: Secreted .

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