Signaling pathway

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HFE Monoclonal Antibody

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Article Number: PH1635
Delivery time: 一周
Price: 100 μL/2200
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Target: HFE
Application: WB, IF, ELISA
Reactivity : Human
MW(CalcμLated) : 40 kD
Host Species: Mouse

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : Affinity purification
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Clonality : Monoclonal

Antigen & Target Information

Specificity : HFE Monoclonal Antibody detects endogenous levels of HFE protein.
Gene name : HFE
Protein Name : Hereditary hemochromatosis protein
Alias : HFE;HLAH;Hereditary hemochromatosis protein;HLA-H

Database connection:

Organism

Gene ID

SwissProt

Mouse
Background:

The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined. [provided by RefSeq, Jul 2008],

Cell localization : Cell membrane ; Single-pass type I membrane protein .

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