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Signaling pathway
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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
Article Number: PH0426
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
Category:
Target： p120 Catenin
Application： IHC, WB, IF, ELISA
Reactivity ： Human,Mouse,Rat,
MW(CalcμLated) ： 108 kD
MW(Observed) ： 110 kD
Host Species： Mouse
Isotype ： IgG2b, Kappa
隐藏域元素占位
Detailed Information
Recommended dilution ratio ： IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000
Compose ： PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process ： Protein G
Storage ： -15°C to -25°C/1 year(Do not lower than -25°C
Clonality ： Monoclonal
Clone Number ： ABT-p120
Antigen & Target Information
Specificity ： The antibody can specifically recognize human p120 catenin protein. In western blotting of Hela, A431 and HEK293 cell lysates, the antibody can label a band with molecular weight around 100~110 kDa.
Gene name ： CTNND1 KIAA0384
Protein Name ： p120 catenin
Alias ： Cadherin-associated Src substrate; Cadherin-associated Src substrate; CAS; Catenin; cadherin-associated protein; delta 1; Catenin delta 1; Catenin delta; Catenin delta-1; CTND1_HUMAN; CTNND 1; CTNND; CTNND1; delta 1 Catenin; KIAA0384; p120; P120 CAS; p120 catenin; P120 CTN; p120; cas; p120; ctn; P120CAS; P120CTN
Background：
α-Catenin, β-catenin, γ-catenin, and p120-catenin are members of the catenin family and mediate intercellular adhesion together with E-cadherin. P120-catenin binds to the near-membrane region of E-cadherin to form a stable, tightly associated complex. In lobular breast cancer, E-cadherin deficiency leads to the accumulation of p120-catenin in the cytoplasm, whereas in ductal breast cancer, p120-catenin levels at the membrane decrease, with no significant accumulation in the cytoplasm. Therefore, this pattern can be used to differentiate lobular carcinoma from ductal carcinoma. Studies have demonstrated that cytoplasmic p120-catenin in gastric and colorectal cancers correlates with impaired cell adhesion.
Cell localization ： Cytoplasmic, Membranous
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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
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