Signaling pathway

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14-3-3-pan rabbit pAb

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Article Number: PD0353
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: 14-3-3-pan
Application: WB, ELISA
Reactivity : Human,Mouse,Rat
MW(CalcμLated) : 27 kD
MW(Observed) : 30 kD
Host Species: Rabbit
Isotype : IgG

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Detailed Information

Recommended dilution ratio : WB 1:1000-2000; ELISA 1:5000-20000
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : This antibody detects endogenous levels of Human,Mouse,Rat 14-3-3-pan
Gene name : YWHAB
Protein Name : 14-3-3-pan
Alias : 14-3-3 protein beta/alpha; Protein 1054; Protein kinase C inhibitor protein 1; KCIP-1; [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]

Database connection:

Background:

This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008],

Cell localization : Cytoplasm . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.; Vacuole membrane . (Microbial infection) Upon infection with Chlamydia trachomatis, this protein is associated with the pathogen-containing vacuole membrane where it colocalizes with IncG. .

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