Signaling pathway

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Mcl-1 Monoclonal Antibody

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Article Number: PH1560
Delivery time: 一周
Price: 100 μL/2200
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Target: Mcl-1
Application: WB, IHC, IF, ELISA
Reactivity : Human
MW(Observed) : 40kD in human,39kD in mouse and rat
Host Species: Mouse

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-1:2000;IHC 1:200-1:1000;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : Affinity purification
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Clonality : Monoclonal

Antigen & Target Information

Specificity : Mcl-1 Monoclonal Antibody detects endogenous levels of Mcl-1 protein.
Gene name : MCL1
Protein Name : Induced myeloid leukemia cell differentiation protein Mcl-1
Alias : MCL1;BCL2L3;Induced myeloid leukemia cell differentiation protein Mcl-1;Bcl-2-like protein 3;Bcl2-L-3;Bcl-2-related protein EAT/mcl1;mcl1/EAT

Database connection:

Organism

Gene ID

SwissProt

Mouse
Background:

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010],

Cell localization : Membrane; Single-pass membrane protein. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Cytoplasmic, associated with mitochondria.

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