Signaling pathway

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M3K12 Polyclonal Antibody

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Article Number: PG7125
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: M3K12
Application: WB, ELISA
Reactivity : Human,Mouse,Rat
MW(Observed) : 94 kD
Host Species: Rabbit
Isotype : IgG

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Detailed Information

Recommended dilution ratio : WB 1:500-2000; ELISA 1:5000-20000
Compose : PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : M3K12 Polyclonal Antibody detects endogenous levels of protein.
Gene name : MAP3K12 ZPK
Protein Name : Mitogen-activated protein kinase kinase kinase 12 (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase)

Database connection:

Organism

Gene ID

SwissProt

Mouse
Background:

This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010],

Cell localization : Cytoplasm . Cell membrane . Behaves essentially as an integral membrane protein. .

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