Signaling pathway

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GP161 Polyclonal Antibody

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Article Number: PG6226
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: GP161
Application: WB, ELISA
Reactivity : Human,Mouse
MW(Observed) : 58 kD
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-2000; ELISA 1:5000-20000
Compose : PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : GP161 Polyclonal Antibody detects endogenous levels of protein.
Gene name : GPR161
Protein Name : G-protein coupled receptor 161 (G-protein coupled receptor RE2)

Database connection:

Organism

Gene ID

SwissProt

Mouse
Background:

Upon ligand binding, G protein-coupled receptors, such as GPR161, activate cytoplasmic G proteins (see GNAS, MIM 139320), allowing the receptors to transduce extracellular signals across the plasma membrane into the cell. Phosphorylation of the receptor attenuates signaling (Matteson et al., 2008 [PubMed 18250320]).[supplied by OMIM, Aug 2008],

Cell localization : Cell projection, cilium membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Mainly localizes to primary cilium in a TULP3 and IFT-A complex-dependent manner. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes and is apparently not degraded (By similarity). .

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