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Email: pinuofei2017@163.com
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Article Number: PL0421
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
Category:
Target： ALPL
Application： WB, IHC, IF, IP, ELISA
Reactivity ： Human,Mouse,Rat
MW(CalcμLated) ： 57 kD
MW(Observed) ： 80 kD
Host Species： Rabbit
Isotype ： IgG, Kappa
隐藏域元素占位
Detailed Information
Recommended dilution ratio ： IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200;
Compose ： PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process ： Protein A
Storage ： -15°C to -25°C/1 year(Do not lower than -25°C
Clonality ： Monoclonal
Clone Number ： PT1342R
Antigen & Target Information
Specificity ： Endogenous
Gene name ： ALPL
Protein Name ： Alkaline phosphatase tissue-nonspecific isozyme
Alias ： ALPL; Alkaline phosphatase; tissue-nonspecific isozyme; AP-TNAP; TNSALP; Alkaline phosphatase liver/bone/kidney isozyme
Database connection:
Background：
This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015]
Cell localization ： Catalytic activity: A phosphate monoester + H(2)O = an alcohol + phosphate. Cofactor: Binds 1 magnesium ion. Cofactor: Binds 2 zinc ions. Disease: Defects in ALPL are a cause of hypophosphatasia adult type (hypophosphatasia) [MIM:146300]. Disease: Defects in ALPL are a cause of hypophosphatasia childhood (hypophosphatasia) [MIM:241510]. Disease: Defects in ALPL are a cause of hypophosphatasia infantile (hypophosphatasia) [MIM:241500]; an inherited metabolic bone disease characterized by defective skeletal mineralization. Four hypophosphatasia forms are distinguished, depending on the age of onset: perinatal, infantile, childhood and adult type. The perinatal form is the most severe and is almost always fatal. Patients with only premature loss of deciduous teeth, but with no bone disease are regarded as having odontohypophosphatasia (odonto). Function: This isozyme may play a role in skeletal mineralization. Miscellaneous: In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney). Online information: Alkaline phosphatase entry. Online information: Tissue nonspecific alkaline phosphatase gene mutations database. PTM: Glycosylated. Similarity: Belongs to the alkaline phosphatase family. Subunit: Homodimer.
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