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RO60 Polyclonal Antibody

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Article Number: PD3684
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: RO60
Application: WB, IHC
Reactivity : Human,Mouse
MW(Observed) : 70 kD
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-2000;IHC 1:50-300
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : RO60 Polyclonal Antibody detects endogenous levels of RO60 protein.
Gene name : TROVE2
Protein Name : 60 kDa SS-A/Ro ribonucleoprotein
Alias : TROVE2;RO60;SSA2;60 kDa SS-A/Ro ribonucleoprotein;60 kDa Ro protein;60 kDa ribonucleoprotein Ro;RoRNP;Ro 60 kDa autoantigen;Sjoegren syndrome antigen A2;Sjoegren syndrome type A antigen;SS-A;TROVE domain family member 2

Database connection:

Organism

Gene ID

SwissProt

Mouse
Background:

disease: Sera from patients with systemic lupus erythematosus (SLE) often contain antibodies that react with the normal cellular SSA2 protein as if this antigen was foreign. function: RNA-binding protein that binds to several small cytoplasmic RNA molecules known as Y RNAs. May stabilize these RNAs from degradation. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Belongs to the Ro 60 kDa family. similarity: Contains 1 TROVE domain. subunit: Found in a complex with PUF60 and Y5 RNA. Interacts with RIP11.

Cell localization : Cytoplasm . Localized in cytoplasmic mRNP granules containing untranslated mRNAs. .

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