Signaling pathway

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PP2Cε Polyclonal Antibody

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Article Number: PD3968
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: PP2Cε
Application: WB, IHC
Reactivity : Human,Mouse,Rat
MW(Observed) : 42 kDa
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-2000;IHC 1:50-300
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : PP2Cε Polyclonal Antibody detects endogenous levels of PP2Cε protein.
Gene name : PPM1L
Protein Name : Protein phosphatase 1L
Alias : PPM1L;PP2CE;Protein phosphatase 1L;Protein phosphatase 1-like;Protein phosphatase 2C isoform epsilon;PP2C-epsilon

Database connection:

Organism

Gene ID

SwissProt

Background:

The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015],

Cell localization : Membrane ; Single-pass type I membrane protein .

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