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Article Number: PD4497
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
Category:
Target: NUB1
Application: WB, IHC, IF, ELISA
Reactivity : Human,Mouse,Monkey
MW(Observed) : 70 kD
Host Species: Rabbit
Isotype : IgG
隐藏域元素占位
Detailed Information
Recommended dilution ratio : WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal
Antigen & Target Information
Specificity : NUB1 Polyclonal Antibody detects endogenous levels of NUB1 protein.
Gene name : NUB1
Protein Name : NEDD8 ultimate buster 1
Alias : NUB1;NYREN18;NEDD8 ultimate buster 1;Negative regulator of ubiquitin-like proteins 1;Renal carcinoma antigen NY-REN-18
Background:
This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splici


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