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MGMT Polyclonal Antibody

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Article Number: PD4882
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: MGMT
Application: WB, IHC, IF, ELISA
Reactivity : Human, Rat
MW(Observed) : 22 kD
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : MGMT Polyclonal Antibody detects endogenous levels of MGMT protein.
Gene name : MGMT
Protein Name : Methylated-DNA--protein-cysteine methyltransferase
Alias : MGMT; Methylated-DNA–protein-cysteine methyltransferase; 6-O-methylguanine-DNA methyltransferase; MGMT; O-6-methylguanine-DNA-alkyltransferase

Database connection:

Organism

Gene ID

SwissProt

Mouse
Background:

Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015],

Cell localization : Nucleus.

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