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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
Article Number: PD5150
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
Category:
Target： JMJD2B
Application： IHC, IF, ELISA
Reactivity ： Human,Mouse
MW(CalcμLated) ： 122 kD
Host Species： Rabbit
Isotype ： IgG
隐藏域元素占位
Detailed Information
Recommended dilution ratio ： IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200
Compose ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage ： -15°C to -25°C/1 year(Do not lower than -25°C
Concentration ： 1 mg/ml
Clonality ： Polyclonal
Antigen & Target Information
Specificity ： JMJD2B Polyclonal Antibody detects endogenous levels of JMJD2B protein.
Gene name ： KDM4B
Protein Name ： Lysine-specific demethylase 4B
Alias ： KDM4B;JHDM3B;JMJD2B;KIAA0876;Lysine-specific demethylase 4B;JmjC domain-containing histone demethylation protein 3B;Jumonji domain-containing protein 2B
Background：
cofactor: Binds 1 Fe(2+) ion per subunit. domain: The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails. function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. similarity: Belongs to the JHDM3 histone demethylase family. similarity: Contains 1 JmjC domain. similarity: Contains 1 JmjN domain. similarity: Contains 2 PHD-type zinc fingers. similarity: Contains 2 Tudor domains.
Cell localization ： Nucleus .
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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
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