Signaling pathway

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IFI-16 Polyclonal Antibody

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Article Number: PD5263
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: IFI-16
Application: WB, ELISA
Reactivity : Human,
MW(Observed) : 88 kD
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-1:2000;ELISA 1:40000;Not yet tested in other applications.
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : IFI-16 Polyclonal Antibody detects endogenous levels of IFI-16 protein.
Gene name : IFI16
Protein Name : Gamma-interferon-inducible protein 16
Alias : IFI16;IFNGIP1;Gamma-interferon-inducible protein 16;Ifi-16;Interferon-inducible myeloid differentiation transcriptional activator

Database connection:

Organism

Gene ID

SwissProt

Background:

This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011],

Cell localization : Nucleus. Cytoplasm. Cellular distribution is dependent on the acetylation status of the multipartite nuclear localization signal (NLS); NLS acetylation promotes cytoplasmic localization. Localizes in the nucleus during human herpes simplex virus 1 (HHV-1) infection.

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