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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
Article Number: PD5338
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
Target： HM74
Application： WB, IF, ELISA
Reactivity ： Human,Mouse,Rat
MW(Observed) ： 45 kD
Host Species： Rabbit
Isotype ： IgG
隐藏域元素占位
Detailed Information
Recommended dilution ratio ： WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.
Compose ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage ： -15°C to -25°C/1 year(Do not lower than -25°C
Concentration ： 1 mg/ml
Clonality ： Polyclonal
Antigen & Target Information
Specificity ： HM74 Polyclonal Antibody detects endogenous levels of HM74 protein.
Gene name ： HCAR2/HCAR3
Protein Name ： HM74A/HM74B
Alias ： HCAR3;GPR109B;HCA3;HM74B;NIACR2;Hydroxycarboxylic acid receptor 3;G-protein coupled receptor 109B;G-protein coupled receptor HM74;G-protein coupled receptor HM74B;Niacin receptor 2;Nicotinic acid receptor 2;HCAR2;GPR109A;HCA2;Hydroxycarboxylic acid receptor 2;
Database connection:
Background：
developmental stage: Expression in neutrophils occurs in the late terminal differentiation phase. Function: Acts as a high-affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate, mediating increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels, which may affect the activity of cAMP-dependent protein kinase A and the phosphorylation of target proteins, leading to neutrophil apoptosis. Miscellaneous: The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. Similarity: Belongs to the G-protein coupled receptor 1 family. Tissue specificity: Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils.
Cell localization ： Cell membrane; Multi-pass membrane protein.
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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
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