Signaling pathway

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NEDD4L (Phospho Ser448) rabbit pAb

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Article Number: PF0519
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: NEDD4L
Application: World Bank
Reactivity : Human, Rat, Mouse,
MW(Observed) : 110-120 kD
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Modify-Modification : Phospho
Recommended dilution ratio : WB 1:1000-2000
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : This antibody detects endogenous levels of Human NEDD4L (phospho-Ser448)
Gene name : NEDD4L KIAA0439 NEDL3
Protein Name : NEDD4L (Ser448)
Alias : E3 ubiquitin-protein ligase NEDD4-like;NEDD4.2;Nedd4-2;

Database connection:

Organism

Gene ID

SwissProt

Mouse
Background:

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012],

Cell localization : Cytoplasm . Golgi apparatus . Endosome, multivesicular body . May be recruited to exosomes by NDFIP1.

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