Signaling pathway

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IGF-I Receptor β (Phospho Tyr980) rabbit pAb

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Article Number: PF0570
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: IGF-1R
Application: World Bank
Reactivity : Human,Mouse,Rat
MW(Observed) : pro:155 kD, beta receptor: 95 kD
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Modify-Modification : Phospho
Recommended dilution ratio : WB 1:1000-2000
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : This antibody detects endogenous levels of Human Mouse Rat IGF-I Receptor β (phospho-Tyr980)
Gene name : IGF1R
Protein Name : IGF-I Receptor β (Tyr980)
Alias : Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221; [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]

Database connection:

Organism

Gene ID

SwissProt

Background:

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014],

Cell localization : Cell membrane ; Single-pass type I membrane protein .

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