Signaling pathway

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HDAC7 (phospho Ser155) Polyclonal Antibody

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Article Number: PF1422
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: HDAC7
Application: WB, ELISA
Reactivity : Human,Mouse,Rat
MW(Observed) : 103 kD
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Modify-Modification : Phospho
Recommended dilution ratio : WB 1:500-1:2000;ELISA 1:40000;Not yet tested in other applications.
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : Phospho-HDAC7 (S155) Polyclonal Antibody detects endogenous levels of HDAC7 protein only when phosphorylated at S155.
Gene name : HDAC7
Protein Name : Histone deacetylase 7
Alias : HDAC7;HDAC7A;Histone deacetylase 7;HD7;Histone deacetylase 7A;HD7a

Database connection:

Organism

Gene ID

SwissProt

Background:

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Cell localization : Nucleus. Cytoplasm. In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.

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