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RUNX1 (phospho Ser435) Polyclonal Antibody

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Article Number: PF1457
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: RUNX1
Application: WB, ELISA
Reactivity : Human,Mouse,Rat
MW(Observed) : 53 kD
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Modify-Modification : Phospho
Recommended dilution ratio : WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : Phospho-RUNX1 (S435) Polyclonal Antibody detects endogenous levels of RUNX1 protein only when phosphorylated at S435.
Gene name : RUNX1
Protein Name : Runt-related transcription factor 1
Alias : RUNX1; AML1; CBFA2; Runt-related transcription factor 1; Acute myeloid leukemia 1 protein; Core-binding factor subunit alpha-2; CBF-alpha-2; Oncogene AML-1; Polyomavirus enhancer-binding protein 2 alpha B subunit; PEA2-alpha B; PEBP2-alpha

Database connection:

Organism

Gene ID

SwissProt

Background:

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Cell localization : Nucleus.

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