Signaling pathway

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NRBP Polyclonal Antibody

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Article Number: PG6835
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: NRBP
Application: WB, ELISA
Reactivity : Human,Mouse
MW(Observed) : 58 kD
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-2000; ELISA 1:5000-20000
Compose : PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : NRBP Polyclonal Antibody detects endogenous levels of protein.
Gene name : NRBP1 BCON3 NRBP
Protein Name : Nuclear receptor-binding protein

Database connection:

Organism

Gene ID

SwissProt

Mouse
Background:

caution:Author states that kinase activity observed in PubMed:11956649 may be due to sample contamination. This protein is predicted to be catalytically inactive.,domain:The protein kinase domain is predicted to be catalytically inactive.,function:May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subcellular location:Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia.,subunit:Homodimer. Binds to MLF1, recruiting a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 binds to YWHAZ and is retained in the cytoplasm.,tissue specificity:Ubiquitously expressed in all tissues examined with high levels in the testis.,

Cell localization : Cytoplasm, cell cortex . Endomembrane system . Cell projection, lamellipodium . Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia.

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