Signaling pathway

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Claudin 18 (ABT158) mouse mAb

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Article Number: PH0256
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: Claudin 18
Application: IHC, ELISA
Reactivity : Human,
MW(CalcμLated) : 28 kD
Host Species: Mouse
Isotype : IgG1, Kappa

隐藏域元素占位

Detailed Information

Recommended dilution ratio : IHC 1:200-400; ELISA 1:500-5000
Compose : PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process : The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Clonality : Monoclonal
Clone Number : ABT158

Antigen & Target Information

Specificity : The antibody can specifically recognize both human Claudin 18.1 and Claudin 18.2 protein.
Gene name : CLDN18 UNQ778/PRO1572
Protein Name : Claudin 18
Alias : Claudin-18

Database connection:

Organism

Gene ID

SwissProt

Background:

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010],

Cell localization : Membranous

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