Signaling pathway

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DPYD (PT1655R) PT™ Rabbit mAb

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Article Number: PL0133
Delivery time: 现货
Price: 100 μL/1800
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Target: DPYD
Application: WB, IHC, IF, ELISA
Reactivity : Human,Mouse,Rat
MW(CalcμLated) : 111 kD
MW(Observed) : 111 kD
Host Species: Rabbit
Isotype : IgG, Kappa

隐藏域元素占位

Detailed Information

Recommended dilution ratio : IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000;
Compose : PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process : Protein A
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Clone Number : Monoclonal

Antigen & Target Information

Specificity : Endogenous
Gene name : DPYD
Protein Name : Dihydropyrimidine dehydrogenase [NADP(+)]
Alias : DPYD; Dihydropyrimidine dehydrogenase [NADP;+;]; DHPDHase; DPD; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase

Database connection:

Organism

Gene ID

SwissProt

Background:

The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009],

Cell localization : Cytoplasm.

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