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Article Number: PL0633
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
Target： BRAT1
Application： WB,FC
Reactivity ： Human
MW(CalcμLated) ： 90 kDa
MW(Observed) ： 90 kDa
Host Species： Rabbit
Isotype ： IgG, Kappa
Conjugate ： Unmodified
隐藏域元素占位
Detailed Information
Recommended dilution ratio ： WB 1:1000-1:5000; FC 1:100-1:500;
Compose ： PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process ： Protein A
Storage ： -15°C to -25°C/1 year(Do not lower than -25°C
Clone Number ： PT1113R
Antigen & Target Information
Specificity ： Endogenous
Gene name ： BRAT1;BAAT1;C7orf27
Protein Name ： BRCA1-associated ATM activator 1; BRCA1-associated protein required for ATM activation protein 1;
Alias ： BRAT1;BAAT1;C7orf27;BRCA1-associated ATM activator 1 ;BRCA1-associated protein required for ATM activation protein 1;
Background：
The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM. [provided by RefSeq, Mar 2012]
Cell localization ： Nucleus. Cytoplasm. Note=Present at double strand breaks (DSBs)following ionizing radiation treatment. The ubiquitinated form localizes in the nucleus in a NDFIP1-dependent manner..
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