Signaling pathway

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Trk B Rabbit mAb

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Article Number: PL0686
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: Track B
Application: WB, IHC, IF, ELISA
Reactivity : Human,Mouse,Rat
MW(CalcμLated) : 92 kD
MW(Observed) : 130 kD
Host Species: Rabbit
Isotype : IgG, Kappa
Conjugate : Unmodified

隐藏域元素占位

Detailed Information

Recommended dilution ratio : IHC 1:100-1:500; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000;
Compose : PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process : Protein A
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Clonality : Monoclonal
Clone Number : PT1150R

Antigen & Target Information

Specificity : Endogenous
Gene name : NTRK2
Protein Name : BDNF/NT-3 growth factors receptor
Alias : NTRK2;TRKB;BDNF/NT-3 growth factors receptor;GP145-TrkB;Trk-B;Neurotrophic tyrosine kinase receptor type 2;TrkB tyrosine kinase;Tropomyosin-related kinase B

Database connection:

Organism

Gene ID

SwissProt

Background:

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],

Cell localization : Cell membrane ; Single-pass type I membrane protein . Endosome membrane ; Single-pass type I membrane protein . Early endosome membrane . Cell projection, axon . Cell projection, dendrite . Cytoplasm, perinuclear region . Cell junction, synapse, postsynaptic density . Internalized to endosomes upon ligand-binding. .

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