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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
Article Number: PL0823
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
Category:
Target： NMDAR2B
Application： WB, IF, ELISA
Reactivity ： Human,Mouse,Rat
MW(CalcμLated) ： 166 kD
MW(Observed) ： 190 kD
Host Species： Rabbit
Isotype ： IgG, Kappa
隐藏域元素占位
Detailed Information
Recommended dilution ratio ： WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000;
Compose ： PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process ： Protein A
Storage ： -15°C to -25°C/1 year(Do not lower than -25°C
Clonality ： Monoclonal
Clone Number ： PT0999R
Antigen & Target Information
Specificity ： Endogenous
Gene name ： GRIN2B
Protein Name ： Glutamate [NMDA] receptor subunit epsilon-2
Alias ： GRIN2B;NMDAR2B;Glutamate [NMDA] receptor subunit epsilon-2;N-methyl D-aspartate receptor subtype 2B;NMDAR2B;NR2B;N-methyl-D-aspartate receptor subunit 3;NR3;hNR3
Database connection:
Background：
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008],
Cell localization ： Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10) family. Subunit: Forms a heteromeric channel consisting of a zeta subunit (GRIN1), an epsilon subunit (GRIN2A, GRIN2B, GRIN2C, or GRIN2D), and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A, and PPP2CB. Interacts with PDZ domains of INADL and DLG4. Interacts with HIP1 (by similarity). Interacts with MAGI3. Tissue specificity: Primarily found in the fronto-parieto-temporal cortex and hippocampal pyramidal cells, with lower expression in the basal ganglia.
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