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Email: pinuofei2017@163.com
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Article Number: PL0910
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
Target： Doublecortin
Application： WB, IHC, IF, ELISA
Reactivity ： Human,Mouse,Rat
MW(CalcμLated) ： 41 kD
MW(Observed) ： 41 kD
Host Species： Rabbit
Isotype ： IgG, Kappa
Conjugate ： Unmodified
隐藏域元素占位
Detailed Information
Recommended dilution ratio ： IHC 1:50-1:200; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000;
Compose ： PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process ： Protein A
Storage ： -15°C to -25°C/1 year(Do not lower than -25°C
Clonality ： Monoclonal
Clone Number ： PT0871R
Antigen & Target Information
Specificity ： Endogenous
Gene name ： DCX
Protein Name ： Neuronal migration protein doublecortin
Alias ： DCX;DBCN;LISX;Neuronal migration protein doublecortin;Doublin;Lissencephalin-X;Lis-X
Background：
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain")
Cell localization ： Cytoplasm . Cell projection, neuron projection . Localizes at neurite tips. .
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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
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