Signaling pathway

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PINK1 Rabbit mAb

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Article Number: PL0967
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: PINK1
Application: WB, IF, IP, ELISA
Reactivity : Human,Mouse,Rat
MW(CalcμLated) : 63 kDa
MW(Observed) : 63 kDa
Host Species: Rabbit
Isotype : IgG, Kappa
Conjugate : Unmodified

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200;
Compose : PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process : Protein A
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Clone Number : PT0824R

Antigen & Target Information

Specificity : Endogenous
Gene name : PINK1
Protein Name : Serine/threonine-protein kinase PINK1, mitochondrial (BRPK) (PTEN-induced putative kinase protein 1)

Database connection:

Organism

Gene ID

SwissProt

Mouse
Background:

This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008],

Cell localization : Mitochondrion outer membrane ; Single-pass membrane protein . Mitochondrion inner membrane ; Single-pass membrane protein . Cytoplasm, cytosol . Localizes mostly in mitochondrion and the two smaller proteolytic processed fragments localize mainly in cytosol (PubMed:19229105). When mitochondria lose mitochondrial membrane potential following damage, PINK1 import is arrested, which induces its accumulation in the outer mitochondrial membrane, where it acquires kinase activity (PubMed:18957282). .

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