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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
Article Number: PL1317
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
Category:
Target： Ribosomal Protein S6
Application： WB, IHC, IF, IP, ELISA
Reactivity ： Human,Mouse,Rat
MW(CalcμLated) ： 29 kDa
MW(Observed) ： 29 kDa
Host Species： Rabbit
Isotype ： IgG, Kappa
Conjugate ： Phospho
隐藏域元素占位
Detailed Information
Modify-Modification ： Ser240/244
Recommended dilution ratio ： IHC 1:1000-1:4000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200;
Compose ： PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process ： Protein A
Storage ： -15°C to -25°C/1 year(Do not lower than -25°C
Clonality ： Monoclonal
Clone Number ： PT0447R
Antigen & Target Information
Specificity ： This antibody detects endogenous levels of Ribosomal Protein S6 only when phosphorylated at Ser240 or Ser244.
Gene name ： RPS6
Protein Name ： 40S ribosomal protein S6
Alias ： RPS6;OK/SW-cl.2;40S ribosomal protein S6;Phosphoprotein NP33
Database connection:
Background：
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed
Cell localization ： nucleus, nucleoplasm, nucleolus, cytoplasm, cytosol, ribosome, polysome, small ribosomal subunit, membrane, cytosolic small ribosomal subunit, dendrite, intracellular ribonucleoprotein complex, cytoplasmic ribonucleoprotein granule
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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
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