Signaling pathway

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Insulin Receptor β Rabbit mAb

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Article Number: PL1051
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: Insulin R
Application: WB, IHC, IF, IP, ELISA
Reactivity : Human,Mouse,Rat,Pig
MW(CalcμLated) : 95 kD
MW(Observed) : 95 kD
Host Species: Rabbit
Isotype : IgG, Kappa
Conjugate : Unmodified

隐藏域元素占位

Detailed Information

Recommended dilution ratio : IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200;
Compose : PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process : Protein A
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Clonality : Monoclonal
Clone Number : PT0688R

Antigen & Target Information

Specificity : Endogenous
Gene name : INSR
Protein Name : Insulin Receptor β (Tyr1345)
Alias : Insulin receptor; IR; CD antigen CD220; [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]

Database connection:

Organism

Gene ID

SwissProt

Background:

This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],

Cell localization : Membrane

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