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Signaling pathway
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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
Article Number: PH0228
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
Category:
Target： Wilms' Tumor 1
Application： IHC, ELISA
Reactivity ： Human,Mouse,Rat,Pig,
MW(CalcμLated) ： 55 kD
MW(Observed) ： 55 kD
Host Species： Mouse
Isotype ： IgG2b, Kappa
隐藏域元素占位
Detailed Information
Recommended dilution ratio ： IHC 1:50-100; ELISA 1:500-5000
Compose ： PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process ： The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage ： -15°C to -25°C/1 year(Do not lower than -25°C
Clonality ： Monoclonal
Clone Number ： ABT-WT1
Antigen & Target Information
Specificity ： The antibody can specifically recognize human WT1 protein.
Gene name ： WT1
Protein Name ： Wilms tumor protein (WT33)
Background：
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015],
Cell localization ： Nuclear
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Centered on our primary and secondary antibody products, we have established a strong foothold in the specialized antibody reagent market. Leveraging our independently developed core technology platform and a dedicated R&D and manufacturing team, we provide high‑reliability biological reagents and end‑to‑end technical solutions to universities, research institutes, biopharmaceutical companies, and other customers worldwide.
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Wuhan Pinofibio Biotechnology Co., Ltd.
Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
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