Signaling pathway

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Myosin IXb Polyclonal Antibody

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Article Number: PD4708
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: Myosin IXb
Application: WB, ELISA, IHC
Reactivity : Human,Mouse,Rat
MW(Observed) : 250 kD
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : Myosin IXb Polyclonal Antibody detects endogenous levels of Myosin IXb protein.
Gene name : MYO9B
Protein Name : Unconventional myosin-IXb
Alias : MYO9B;MYR5;Unconventional myosin-IXb;Unconventional myosin-9b

Database connection:

Organism

Gene ID

SwissProt

Mouse
Background:

This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],

Cell localization : Cytoplasm, cell cortex . Cytoplasm, perinuclear region . Cytoplasm, cytoskeleton . In undifferentiated cells colocalizes with F-actin in the cell periphery while in differentiated cells its localization is cytoplasmic with the highest levels in the perinuclear region. .

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