Signaling pathway

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FKBP1A/B Polyclonal Antibody

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Article Number: PD1981
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: FKBP1A/B
Application: IHC, IF, WB
Reactivity : Human,Mouse,Rat
MW(Observed) : 130 kD
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Recommended dilution ratio : IHC 1:50-200; WB 1:500-2000; IF 1:50-200
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : This antibody detects endogenous levels of human FKBP1A/B
Protein Name : FKBP1A/B

Database connection:

Organism

Gene ID

SwissProt

Background:

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided b

Cell localization : Cytoplasm, cytosol . Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side .

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